My lab studies the mechanisms underlying neural development, including the establishment of neuronal circuits, using molecular genetic approaches in the mouse. We also model neurodevelopmental disorders using mouse transgenics and cell cultures.

E: Angelo.Iulianella@Dal.ca

My research is dedicated to studying the interneuron circuits controlling locomotor activities in the mouse spinal cord. My lab is one of the few in the field that has been systematically studying spinal interneuron circuits, from their development to their organization and to their functions in locomotor behaviors under physiological and pathological conditions, such as spinal cord injury and ALS diseases.

E: Ying.Zhang@Dal.ca

Our multi-disciplinary research program focuses on molecular, metabolic, and immunological aspects of cellular and behavioural neuroscience, with a special focus on mechanisms of gene regulation. Current projects explore the potential role of chromatin remodeling genes, DNA methylation and DNA repair mechanisms in social, emotional and cognitive development. Additionally, our lab examines altered metabolism and gene regulatory networks in cancer and neurodegenerative disease.

E: Ian.Weaver@Dal.ca

We are currently using a transgenic mouse model of Alzheimer’s disease, a model of perinatal infection, and an adolescent stress model to study the neural bases for peer-to-peer social behaviours. We are also studying differences in epigenetic regulation in the brains of dominant and subordinate mice within naturally formed social hierarchies.

E: Tamara.Franklin@Dal.ca

My research focuses on the neurobiology of chronic pain. We use preclinical models of arthritis to identify novel pain targets to develop innovative pain management strategies.

E: Jason.MacDougall@Dal.ca

My research focuses on novel neuroimaging acquisition and reconstruction/analysis techniques, primarily using MRI. This work spans the use of Artificial Intelligence to improve image quality, through to validation of diagnostic quality for specific clinical questions (e.g., acute ischemia, vestibular Schwannoma, etc).

E: Steven.Beyea@Dal.ca

My research is on optical studies of mechanisms of synaptic plasticity, with a focus on development and use of optical tools, including ultrafast random-access multiphoton excitation fluorescence microscopy and lensless optical microscopy.

E: A.Fine@Dal.ca

My lab uses regenerative medicine strategies to understand and enhance the repair of multiple tissue types including the peripheral nervous system, skeletal muscle and skin. Important to this is understanding the role of the nervous system in regulating tissue repair and how aging and chronic diseases influence nervous system dysfunction.

E: AdamJohnston@dal.ca

My research focuses on:
- The directed differentiation of embryonic stem (ES) and iPS cells into functional motor neurons to repair damaged tissue;
- Restoring meaningful function to completely and permanently denervated skeletal muscles using light activation via channel rhodopsin;
- Understanding the molecular mechanisms underlying synapse stability at the neuromuscular junction in animal models of ALS.

E: Victor.Rafuse@dal.ca

My research focuses primarily on the area of schizophrenia, and my current foci of study include individuals at the early phase of, and individuals at risk for, a psychotic illness, and thus in a youth and young adult population. Areas of research include application of in vivo brain neuroimaging techniques to study psychosis as well as comorbid substance use effects in psychosis (e.g. cannabis) on in vivo brain metabolites and white matter (primarily using MRS and DTI).

E: Phil.Tibbo@nshealth.ca

My research focuses on three different aspects of mouse behaviour:
- developing a set of standardized test batteries (the "Mouse IQ" test) to study the behaviour of inbred, mutant and knockout mice.
- testing mouse models of Alzheimer Disease, Fragile X Syndrome, ADHD and other neurological disorders using our developmental and Mouse IQ test batteries
- testing mouse models of Autism in our test batteries to examine the effects of genetic manipulation of synaptic proteins.

E: Richard.Brown@Dal.Ca

As a behavioural neurologist and trained organic chemist with an interest in medicinal chemistry, my research has been instrumental in determining the importance and expression of butyrylcholinesterase in the human brain. My research focuses on the development of therapeutic and diagnostic agents for Alzheimer’s disease, with butyrylcholinesterase as the target.

E: Sultan.Darvesh@Dal.ca

My research program is based on the premise that to effectively treat neurodegenerative disorders it is necessary to both protect and repair the brain. Mitochondria are specialized organelles that power the chemical reactions in brain cells essential for their operation, survival, and repair. We are developing novel protective and restorative drugs for neurodegenerative disorders that act by preserving and enhancing mitochondrial function in the brain.

E: George.Robertson@Dal.ca

My research focuses on understanding the role of brain vascualar pathologies, specifically blood-brain barrier dysfunction in neuro-psychiatric disorders. We are conducting basic and clinical research to better understand mechanisms of diseases and develop new diagnostic and therapeutic approaches.

E: Alon.Friedman@Dal.ca